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1

Mechanisms of Soft and Hard Electrophile Toxicities

LoPachin, Richard M., Geohagen, Brian C., Nordstroem, Lars U.

Journal:

Year:

2019

Language:

english

File:

PDF, 520 KB

english, 2019

2

β-Dicarbonyl enolates: a new class of neuroprotectants

Richard M. LoPachin, Terrence Gavin, Brian C. Geohagen, Lihai Zhang, Diana Casper, Rukmani Lekhraj, David S. Barber

Journal:

Journal of Neurochemistry

Year:

2011

Language:

english

File:

PDF, 617 KB

english, 2011

3

Structure-Toxicity Analysis of Type-2 Alkenes: In Vitro Neurotoxicity

LoPachin, R. M., Barber, D. S., Geohagen, B. C., Gavin, T., He, D., Das, S.

Journal:

Toxicological Sciences

Year:

2006

Language:

english

File:

PDF, 350 KB

english, 2006

4

Protective Properties of 2-Acetylcyclopentanone in a Mouse Model of Acetaminophen Hepatotoxicity

Zhang, L., Gavin, T., Geohagen, B. C., Liu, Q., Downey, K. J., LoPachin, R. M.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2013

Language:

english

File:

PDF, 556 KB

english, 2013

5

Synaptosomal Toxicity and Nucleophilic Targets of 4-Hydroxy-2-Nonenal

LoPachin, R. M., Geohagen, B. C., Gavin, T.

Journal:

Toxicological Sciences

Year:

2008

Language:

english

File:

PDF, 307 KB

english, 2008

6

Neurotoxic Mechanisms of Electrophilic Type-2 Alkenes: Soft Soft Interactions Described by Quantum Mechanical Parameters

LoPachin, R. M., Gavin, T., Geohagen, B. C., Das, S.

Journal:

Toxicological Sciences

Year:

2007

Language:

english

File:

PDF, 194 KB

english, 2007

7

2-Acetylcyclopentanone, an Enolate-Forming 1,3-Dicarbonyl Compound, Is Cytoprotective in Warm Ischemia-Reperfusion Injury of Rat Liver

Kosharskyy, B., Vydyanathan, A., Zhang, L., Shaparin, N., Geohagen, B. C., Bivin, W., Liu, Q., Gavin, T., LoPachin, R. M.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2015

Language:

english

File:

PDF, 963 KB

english, 2015

8

Enolate-Forming Phloretin Pharmacophores: Hepatoprotection in an Experimental Model of Drug-Induced Toxicity

Geohagen, B. C., Vydyanathan, A., Kosharskyy, B., Shaparin, N., Gavin, T., LoPachin, R. M.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2016

Language:

english

File:

PDF, 1.23 MB

english, 2016

9

Joint toxic effects of the type-2 alkene electrophiles

Zhang, Lihai, Geohagen, Brian C., Gavin, Terrence, LoPachin, Richard M.

Journal:

Chemico-Biological Interactions

Year:

2016

Language:

english

File:

PDF, 1.11 MB

english, 2016

10

ENOLATE-FORMING COMPOUNDS AS A NOVEL APPROACH TO CYTOPROTECTION

LoPachin, Richard Michael, Geohagen, Brian C., Nordstrøm, Lars Ulrik, Gavin, Terrence

Journal:

Chemical Research in Toxicology

Year:

2016

Language:

english

File:

PDF, 4.53 MB

english, 2016

11

Phloretin cytoprotection and toxicity

Geohagen, Brian C., Korsharskyy, Boris, Vydyanatha, Amaresh, Nordstroem, Lars, LoPachin, Richard M.

Journal:

Chemico-Biological Interactions

Year:

2018

Language:

english

File:

PDF, 1.10 MB

english, 2018

12

Mechanisms of Soft and Hard Electrophile Toxicities

LoPachin, Richard M., Geohagen, Brian C., Nordstroem, Lars U.

Journal:

Year:

2019

File:

PDF, 520 KB

2019

13

Application of the hard and soft, acids and bases (HSAB) theory as a method to predict cumulative neurotoxicity

Melnikov, Fjodor, Geohagen, Brian C., Gavin, Terrence, LoPachin, Richard M., Anastas, Paul T., Coish, Phillip, Herr, David W.

Journal:

NeuroToxicology

Year:

2020

File:

PDF, 1.63 MB

2020

14

Enolate-forming compounds provide protection from platinum neurotoxicity

Geohagen, Brian C., Weiser, Daniel A., Loeb, David M., Nordstroem, Lars U., LoPachin, Richard M.

Journal:

Chemico-Biological Interactions

Year:

2020

File:

PDF, 1.52 MB

2020

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